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miRNAExpressionSamplesN samplesPotential biomarkerMethodClinical implicationReference

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hsa-miR-9↑BileBTCs (9)
HV (9)Diagnostic
PrognosticRT-PCRMetastasis[61]

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hsa-miR-145↑BileBTCs (9)
HV (9)DiagnosticRT-PCR—[61]

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hsa-miR-21↑PlasmaBTCs (94)
HV (50)
BBD (2)DiagnosticqRT-PCRInflammatory reaction[62]Peripheral bloodGBC (40)
HV (40)DiagnosticqRT-PCR—[47]

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hsa-miR-150↑PlasmaiCCA (15)DiagnosticqRT-PCRTumor progression[63]

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hsa-miR-106a↓SerumCCA (103)PrognosticqRT-PCRLymph node metastasis[64]HV (20)

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hsa-miR-126↑SerumPSC (40)
CCA (31)
HV (12)DiagnosticRT-PCR—[65]

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hsa-miR-26a↑SerumPSC (40)
CCA (31)
HV (12)DiagnosticRT-PCR—[65]

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hsa-miR-30b↑SerumPSC (40)
CC (31)
HV (12)DiagnosticRT-PCR—[65]

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hsa- miR-122↑SerumPSC (40)
CC (31)
HV (12)DiagnosticRT-PCR—[65]

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hsa-miR-1281↑SerumPSC (40)
CC (31)
HV (12)DiagnosticRT-PCR—[65]

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hsa-miR -187↑Peripheral bloodGBC (40)
HV (40)Diagnostic
Prognostic
PredictiveqRT-PCRLymph node metastasis
Poor prognosis[47]

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hsa-miR-192↑Peripheral bloodGBC (40)
HV (40)Diagnostic
Prognostic
PredictiveqRT-PCRInflammatory reaction
Immune reaction
Lymph node metastasis[47]SerumiCCA (11)
HV (09)Diagnostic
PrognosticmiRNA RT-PCR arrayLymph node metastasis
Poor prognosis[66]

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hsa-miR-194↑SerumCCA (70)
HV (70)DiagnosticqRT-PCRTumor progression[58]

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hsa-miR -202↑Peripheral bloodGBC (40)
HV (40)Diagnostic
Prognostic
PredictiveqRT-PCRLymph node metastasis[47]

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hsa-let- 7a↓Peripheral bloodGBC (40)
HV (40)DiagnosticqRT-PCR—[47]

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hsa-miR -143↓Peripheral bloodGBC (40)
HV (40)Diagnostic
Prognostic
PredictiveqRT-PCRInflammatory and immune reaction
Lymph node metastasis[47]

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hsa-miR-335↓Peripheral bloodGBC (40)
HV (40)DiagnosticqRT-PCR—[47]

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hsa-miR-1307-3p↓PlasmaiCCA (13)
HV (5)DiagnosticqRT-PCR—[67]

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hsa-miR-1275↑PlasmaiCCA (13)
HV (5)DiagnosticqRT-PCR—[67]

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hsa- miR-320b↑PlasmaiCCA (13)
HVs (5)DiagnosticqRT-PCR—[67]

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hsa-miR-874↑PlasmaiCCA (13)
HVs (5)DiagnosticqRT-PCR—[67]

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hsa-miR-483-5p↑PlasmaiCCA (13)
HV (5)DiagnosticqRT-PCR—[67]SerumCCA (70)
HV (70)DiagnosticqRT-PCRTumor progression[58]

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hsa-miR-885-5p↑PlasmaiCCA (13)
HV (5)DiagnosticqRT-PCR—[67]

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hsa-miR-92b-3p↑PlasmaiCCA (13)
HV (5)DiagnosticqRT-PCR—[67]

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hsa-miR-505-3p↑PlasmaiCCA (13)
HV (5)DiagnosticqRT-PCR—[67]

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hsa-miR-6836-3p↑SerumBTCs (98)
HV (150)Diagnostic3D-Gene—[68]

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hsa-miR-6075↑SerumBTCs (98)
HV (150)Diagnostic3D-Gene—[68]

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hsa- miR-4634↑SerumBTCs (98)
HV (150)Diagnostic3D-Gene—[68]

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hsa-miR-4294↓SerumBTCs (98)
HV (150)Diagnostic3D-Gene—[68]

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hsa-miR-6880-5p↓SerumBTCs (98)
HV (150)Diagnostic3D-Gene—[68]

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hsa-miR-6799-5p↓SerumBTCs (98)
HV (150)Diagnostic3D-Gene—[68]

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hsa-miR-125a-3p,↓SerumBTCs (98)
HV (150)Diagnostic3D-GeneTumor progression[68]

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hsa-miR-4530↓SerumBTCs (98)
HV (150)Diagnostic3D-Gene—[68]

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hsa-miR-7114-5p↓SerumBTCs (98)
HV (150)Diagnostic3D-Gene—[68]

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hsa-miR-4476↓SerumBTCs (98)
HV (150)Diagnostic3D-Gene—[68]

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