In the present study, cocrystallization of a new piprazole analogue drug, brexpiprazole (BREX), with coformers such as succinic acid and catechol was carried out using ball milling to address the poor solubility and dissolution rate of the molecule.

The paper provides a prime example where liquid is required for a reaction, but simultaneously inhibits it. The results offer insights into possible regional, seasonal, polymer additive and temperature effects on mechanochemical synthesis.

Polymorphism has been explored in a second sphere adduct using a racemic ligand that also shows racemic polymorphic behavior. The polar nature of the second sphere adduct allowed us to study NLO phenomena.

Co-crystals of dextro-(R,R), levo-(S,S), meso-(R,S) and racemic (R,R–S,S)-tartaric acid with pyrazine were obtained by manual kneading and slurry experiments; upon their reaction with the various tartaric acid forms co-former exchange takes place, according to the sequence of stability [(R,S)-ta]₂·py > (S,S/R,R)-ta·py > (R,R)-ta·py or (S,S)-ta·py.

A study of the MOF formation by grinding together solid reactants in a ball mill reveals interesting aspects of morphology and reactivity; the product could also be activated to exhibit appreciable surface areas (>1300 m²g⁻¹) although washing with solvent was required.